Somasekar (Sekar) Seshagiri leads SGRF’s scientific research activities and is the driving force behind the foundation’s educational outreach activities including conferences. He chairs SGRF’s Nextgen Genomics, Biology, Bioinformatics and Technologies (NGBT) international meeting
A resident of San Francisco Bay Area, Seshagiri is Co-founder and Chief Scientific Officer for ModMab Therapeutics. Before that he spent 21 years at Genentech, most recently as Associate Director and Staff Scientist. During his tenure he established a state-of-the-art genomic laboratory, conducted research in cancer and cell signaling areas and participated in drug development.
His research work has been at the forefront of understanding underlying genetic changes in cancer genomes through systematic identification of somatic mutations in large number of cancer types and subtypes using next generation sequencing and other novel techniques. Seshagiri and team have applied computational methods and functional assays to understand the role of cancer specific mutations in oncogenic signaling leading to new target discovery for therapeutic intervention.
He has authored and co-authored over eighty articles in peer-reviewed journals including Science and Nature. Seshagiri holds a Bachelor of Science in Agriculture and a Master of Science in Biotechnology from Tamil Nadu Agricultural University, Coimbatore, India. He is also a recipient of a Master of Science (Software Engineering) from Golden Gate University, San Francisco, US and a Ph.D. in Genetics from the University of Georgia, Athens, GA, US. He did his postdoctoral work in Oncology and Bioinformatics at Genentech.
Elias R, Tcheuyap VT, Kaushik AK, Singla N, Gao M, Reig Torras O, Christie A, Mulgaonkar A, Woolford L, Stevens C, Kettimuthu KP, Pavia-Jimenez A, Boroughs LK, Joyce A, Dakanali M, Notgrass H, Margulis V, Cadeddu JA, Pedrosa I, Williams NS, Sun X, DeBerardinis RJ, Öz OK, Zhong H, Seshagiri S, Modrusan Z, Cantarel BL, Kapur P, Brugarolas J.
Cell Rep. 2021 Nov 23;37(8):110055. doi: 10.1016/j.celrep.2021.110055.
PMID: 34818533
Kim K, Zhou Q, Christie A, Stevens C, Ma Y, Onabolu O, Chintalapati S, Mckenzie T, Tcheuyap VT, Woolford L, Zhang H, Singla N, Parida PK, Marquez-Palencia M, Pedrosa I, Margulis V, Sagalowsky A, Xie Z, Wang T, Durinck S, Modrusan Z, Seshagiri S, Kapur P, Brugarolas J, Malladi S.
Nat Commun. 2021 Oct 4;12(1):5760. doi: 10.1038/s41467-021-25918-4.
PMID: 34608135
Gupta H, Malaichamy S, Mallipatna A, Murugan S, Jeyabalan N, Suresh Babu V, Ghosh A, Ghosh A, Santhosh S, Seshagiri S, Ramprasad VL, Kumaramanickavel G.
BMC Med Genomics. 2021 Jul 22;14(1):188. doi: 10.1186/s12920-021-01034-6.
PMID: 34294096
Chidiac R, Abedin M, Macleod G, Yang A, Thibeault PE, Blazer LL, Adams JJ, Zhang L, Roehrich H, Jo HN, Seshagiri S, Sidhu SS, Junge HJ, Angers S.
EMBO Mol Med. 2021 Jul 7;13(7):e13977. doi: 10.15252/emmm.202113977. Epub 2021 Jun 9.
PMID: 34105895
Shastry A, Aravind S, Sunil M, Ramesh K, Ashley B, T N, Ramprasad VL, Gupta R, Seshagiri S, Nongthomba U, Phalke S.
Mol Genet Genomic Med. 2021 May;9(5):e1633. doi: 10.1002/mgg3.1633. Epub 2021 May 7.
PMID: 33960727
Suryamohan K, Diwanji D, Stawiski EW, Gupta R, Miersch S, Liu J, Chen C, Jiang YP, Fellouse FA, Sathirapongsasuti JF, Albers PK, Deepak T, Saberianfar R, Ratan A, Washburn G, Mis M, Santhosh D, Somasekar S, Hiranjith GH, Vargas D, Mohan S, Phalke S, Kuriakose B, Antony A, Ustav M Jr, Schuster SC, Sidhu S, Junutula JR, Jura N, Seshagiri S.
Commun Biol. 2021 Apr 12;4(1):475. doi: 10.1038/s42003-021-02030-3.
PMID: 33846513
Zeitler L, Fiore A, Meyer C, Russier M, Zanella G, Suppmann S, Gargaro M, Sidhu SS, Seshagiri S, Ohnmacht C, Köcher T, Fallarino F, Linkermann A, Murray PJ.
Elife. 2021 Mar 1;10:e64806. doi: 10.7554/eLife.64806.
PMID: 33646117
Lakshmi Jayaraj K, Thulasidharan N, Antony A, John M, Augustine R, Chakravartty N, Sukumaran S, Uma Maheswari M, Abraham S, Thomas G, Lachagari VBR, Seshagiri S, Narayanan S, Kuriakose B.
Plant Cell Rep. 2021 Apr;40(4):621-635. doi: 10.1007/s00299-020-02659-0. Epub 2021 Jan 15.
PMID: 33449143
Batra SS, Levy-Sakin M, Robinson J, Guillory J, Durinck S, Vilgalys TP, Kwok PY, Cox LA, Seshagiri S, Song YS, Wall JD.
Gigascience. 2020 Dec 7;9(12):giaa134. doi: 10.1093/gigascience/giaa134.
PMID: 33283855
Ahamed H, Balegadde AV, Menon S, Menon R, Ramachandran A, Mathew N, Natarajan KU, Nair IR, Kannan R, Shankar M, Mathew OK, Nguyen TT, Gupta R, Stawiski EW, Ramprasad VL, Seshagiri S, Phalke S.
Sci Rep. 2020 Nov 26;10(1):20610. doi: 10.1038/s41598-020-77124-9.
PMID: 33244021
Suryamohan K, Seshagiri S.
Trends Genet. 2020 Oct;36(10):804-806. doi: 10.1016/j.tig.2020.06.007. Epub 2020 Aug 4.
PMID: 32768150
Suryamohan K, Krishnankutty SP, Guillory J, Jevit M, Schröder MS, Wu M, Kuriakose B, Mathew OK, Perumal RC, Koludarov I, Goldstein LD, Senger K, Dixon MD, Velayutham D, Vargas D, Chaudhuri S, Muraleedharan M, Goel R, Chen YJ, Ratan A, Liu P, Faherty B, de la Rosa G, Shibata H, Baca M, Sagolla M, Ziai J, Wright GA, Vucic D, Mohan S, Antony A, Stinson J, Kirkpatrick DS, Hannoush RN, Durinck S, Modrusan Z, Stawiski EW, Wiley K, Raudsepp T, Kini RM, Zachariah A, Seshagiri S.
Nat Genet. 2020 Jan;52(1):106-117. doi: 10.1038/s41588-019-0559-8. Epub 2020 Jan 6.
PMID: 31907489
GenomeAsia100K Consortium.
Nature. 2019 Dec;576(7785):106-111. doi: 10.1038/s41586-019-1793-z. Epub 2019 Dec 4.
PMID: 31802016
Somasekar (Sekar) Seshagiri leads SGRF’s scientific research activities and is the driving force behind the foundation’s educational outreach activities including conferences. He chairs SGRF’s Nextgen Genomics, Biology, Bioinformatics and Technologies (NGBT) international meeting
A resident of San Francisco Bay Area, Seshagiri is Co-founder and Chief Scientific Officer for ModMab Therapeutics. Before that he spent 21 years at Genentech, most recently as Associate Director and Staff Scientist. During his tenure he established a state-of-the-art genomic laboratory, conducted research in cancer and cell signaling areas and participated in drug development.
His research work has been at the forefront of understanding underlying genetic changes in cancer genomes through systematic identification of somatic mutations in large number of cancer types and subtypes using next generation sequencing and other novel techniques. Seshagiri and team have applied computational methods and functional assays to understand the role of cancer specific mutations in oncogenic signaling leading to new target discovery for therapeutic intervention.
He has authored and co-authored over eighty articles in peer-reviewed journals including Science and Nature. Seshagiri holds a Bachelor of Science in Agriculture and a Master of Science in Biotechnology from Tamil Nadu Agricultural University, Coimbatore, India. He is also a recipient of a Master of Science (Software Engineering) from Golden Gate University, San Francisco, US and a Ph.D. in Genetics from the University of Georgia, Athens, GA, US. He did his postdoctoral work in Oncology and Bioinformatics at Genentech.